Amivantamab as a salvage therapy post-EGFR-tyrosine kinase inhibitor failure in patients with mutated EGFR non-small cell lung cancer

This pilot study suggests that adding late-line amivantamab to an ongoing EGFR-TKI may have potential benefits in selected non-small cell lung cancer (NSCLC) patients with EGFR mutations, but resulted in high skin toxicity. Patients with EGFR L858R mutations appeared to show improved responses to amivantamab compared to the lack of response with ex19dels, while acquired resistance was associated with loss of the original EGFR driver mutation and MET alterations. However, these preliminary findings lack robust evidence due to study limitations, and larger, prospective, multi-center trials are needed to validate these results.