New optical biopsy of tissue using terahertz Raman spectroscopy (Conference Presentation)

The THz-Raman spectra from 5cm-1 to ~333 cm-1 were measured to investigate the inter- and intra-molecular motions that occur in the state of the tissue being normal or diseased. The molecular processes from the THz Raman spectra are used as a biomarker to characterize different tissue states, such as neurological (Alzheimer’s Disease), cancerous, diabetic and metabolism states. In this study, we used the THz-Raman spectroscopy to investigate normal and cancerous tissues of brain and skin melanoma, kidney diseases, key animo acids such as tryptophan, and collagen. The metabolism, aging, and degradation of ex vivo chicken tissues were also studied.