Exploring the effect of subtotal resection on survival outcome in glioblastoma: a case study

Glioblastoma characterized by aggressive nature and poor prognosis remains a challenging entity in neuro-oncology. Standard treatment modalities, including maximal safe surgical resection followed by adjuvant chemotherapy and radiotherapy, aim to prolong survival and alleviate symptoms. However, despite these interventions, prognosis remains dismal, particularly in cases of subtotal resection. This case study delves into the effect of subtotal resection on survival outcomes in glioblastoma patients. A 46-year-old male presented with symptoms of headache and left-sided weakness, prompting admission and subsequent surgical intervention. Subtotal resection, achieving approximately 95 % tumor removal, was performed. Following surgery, the patient underwent chemotherapy with temozolomide (75 mg/m2) for six weeks, omitting radiotherapy. Remarkably, the patient experienced symptom alleviation post-treatment and survived for six months. This case highlights the potential of subtotal resection in managing glioblastoma, particularly in cases where complete excision is not feasible. Additionally, it underscores the need for individualized treatment approaches and further research to optimize outcomes in glioblastoma patients with less favorable prognoses.