Falsely Elevated Estradiol Levels Due to Heterophile Antibody Interference: A Case Report and Literature Review

The rapid identification of interference in estradiol testing poses a challenge for laboratory staff; however, it is vital for preventing unnecessary medical treatment and reducing healthcare costs. Analytical interference should be suspected when clinical manifestations do not align with laboratory results. Consequently, clinicians and laboratory personnel need to develop an anti- interference workflow to mitigate such occurrences in the future.