Elevated VRK1 levels after androgen deprivation therapy promote prostate cancer progression by upregulating YAP1 expression
VRK1 serves as a prognostic marker in PCa, regulated by AR signaling. VRK1 depletion inhibited cell proliferation both in vitro and in vivo, while elevated VRK1 upregulated YAP1, promoting cell proliferation and therapeutic resistance.
Authors
- Hangbin Ma
- Chenchen Chen
- Cheng Zhou (ORCID: https://orcid.org/0000-0002-1557-4694)
- Xuetao Hu
- Jianchao Ge
- Wandong Yu (ORCID: https://orcid.org/0000-0002-8161-771X)
- Yaozong Xu (ORCID: https://orcid.org/0009-0003-6413-6011)
- Yibo Meng (ORCID: https://orcid.org/0009-0009-0370-5456)
- Xilong Wang (ORCID: https://orcid.org/0009-0001-1914-7665)
- Yinghao Zhou
- Guowei Shi (ORCID: https://orcid.org/0000-0002-4084-9426)
- Jun Zhang (ORCID: https://orcid.org/0000-0003-1849-9199)
Institutions
- Fudan University (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1007/s00432-025-06168-z
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00