Co( <scp>ii</scp> )-catalyzed isomerization of enals using hydrogen atom transfer
To develop a process for the synthesis of an enal acetate, the so called C5-acetate that is important in the industrial preparation of vitamin A, we show here that Co(II)-based hydrogen atom transfer catalysts under H<sub>2</sub> promote such isomerizations in high yield with low catalyst loading (0.1 mol%). D-labelling studies suggest the enal isomerization process and catalyst activation by H<sub>2</sub> to be reversible.
Authors
- Rylan J. Lundgren (ORCID: https://orcid.org/0000-0002-7760-6946)
- Qiqige Qiqige
- Mathias Schelwies (ORCID: https://orcid.org/0000-0002-5057-5684)
- Edward Richmond (ORCID: https://orcid.org/0000-0001-8068-2379)
- Rocco Paciello
Institutions
- University of Alberta (CA)
- BASF (Germany) (DE)
- Robert Bosch (Germany) (DE)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4cc06075j
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00