Epithelial-to-Mesenchymal Transition Supports Pancreatic Cancer Evolution

Major Finding: EMT-associated genomic instability promotes tumor heterogeneity and aggressive clinical behavior.Concept: Mesenchymal cells exhibit increased chromatin accessibility that leads to catastrophic cell division.Impact: Eliminating cells that display mesenchymal plasticity may slow the progression of pancreatic cancer.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-030
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
0.00
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article

Epithelial-to-Mesenchymal Transition Supports Pancreatic Cancer Evolution

Cancer Discovery
Epigenetics and DNA Methylation
article

Epithelial-to-Mesenchymal Transition Supports Pancreatic Cancer Evolution

article en

Abstract

Major Finding: EMT-associated genomic instability promotes tumor heterogeneity and aggressive clinical behavior.Concept: Mesenchymal cells exhibit increased chromatin accessibility that leads to catastrophic cell division.Impact: Eliminating cells that display mesenchymal plasticity may slow the progression of pancreatic cancer.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 95%
Epigenetics and DNA Methylation
DOISourceOpenAlex
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Epithelial-to-Mesenchymal Transition Supports Pancreatic Cancer Evolution · Cancer Discovery (2025) | TGRS Research Map | TGRS