A Solitary Plexiform Neurofibroma Mimicking Parotid Tumor: A Rare Case Report

Our case report describes an uncommon occurrence of a solitary plexiform neurofibroma in the salivary gland, which is generally associated with neurofibromatosis-1 (NF-1) but, in this case, arose independently. A 6-year-old girl presented with a painless, progressively enlarging mass in the right parotid region over a span of five years. Histopathological analysis revealed a variety of cellular elements, such as Schwann cells, perineurial cells, axons, and fibroblasts, with S100 immunohistochemistry confirming the diagnosis. This case highlights the importance of identifying solitary plexiform neurofibromas in the salivary gland, even without NF-1, and stresses the need for prompt diagnosis and treatment for optimal management.