Olfactory mucosal mesenchymal stem cell-derived exosome Lnc A2M-AS1 ameliorates oxidative stress by regulating TP53INP1-mediated mitochondrial autophagy through interacting with IGF2BP1 in Parkinson’s diseases
Collectively, lncRNA A2M-AS1 from OM-MSC-derived exosomes regulates TP53INP1 expression by targeting IGF2BP1 to induce mitophagy and ameliorate oxidative stress. OM-MSC-derived exosomes could potentially serve as promising candidates for new treatment methods for PD.
Authors
- Jiangshan Zhang (ORCID: https://orcid.org/0000-0002-3029-5087)
- Dan Hou (ORCID: https://orcid.org/0009-0003-9501-4180)
- Guoshuai Yang (ORCID: https://orcid.org/0000-0003-4824-9457)
- Yanhui Zhou (ORCID: https://orcid.org/0009-0004-2581-1130)
- Chuang Wang (ORCID: https://orcid.org/0000-0002-6394-3730)
- Ying Xia (ORCID: https://orcid.org/0000-0002-8519-3635)
Institutions
- Central South University (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1007/s10565-025-10009-7
- Citations
- 1
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81