Autoantibodies to apolipoprotein A-I in hepatitis C virus infection: a role in disease progression?
CHC is often associated with AAA-I, and these can persist after SVR. AAA-I is a robust predictor of cirrhosis in CHC infection. LX-2 cells exposed to AAA-I showed increased FN. Further studies are warranted to define the role of AAA-I in promoting not only viral persistence but also fibrosis.
Authors
- Margaret F. Bassendine (ORCID: https://orcid.org/0000-0002-0958-9232)
- John K. Lodge (ORCID: https://orcid.org/0000-0001-6014-4952)
- R. Dermot G. Neely (ORCID: https://orcid.org/0009-0003-6597-1596)
- Simon D. Taylor‐Robinson (ORCID: https://orcid.org/0000-0002-8811-1834)
- Matthew Cramp (ORCID: https://orcid.org/0000-0002-1152-0568)
- Isaac Thom Shawa (ORCID: https://orcid.org/0000-0001-5236-6467)
- Simon H. Bridge (ORCID: https://orcid.org/0000-0002-6212-3255)
- Nicolas Vuilleumier (ORCID: https://orcid.org/0000-0002-1122-438X)
- David Sheridan (ORCID: https://orcid.org/0000-0001-5100-814X)
- Sabrina Pagano
- Paula Marin-Crespo
Institutions
- University of Geneva (CH)
- London Metropolitan University (GB)
- University of Derby (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Northumbria University (GB)
- University Hospital of Geneva (CH)
- Imperial College London (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1461041
- Primary Topic
- Hepatitis C virus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council