Accuracy of plasma biomarkers to detect Alzheimer's disease proteinopathy prior to dementia
C<sub>2</sub>N plasma biomarkers differentiated Alzheimer's disease proteinopathy status prior to dementia. Plasma %phosphorylated tau (p-tau)217 and the C<sub>2</sub>N Diagnostics PrecivityAD2 (APS2) were concordant with amyloid and tau positron emission tomography status. Plasma %p-tau217 and the APS2 were associated with preclinical cognitive decline.
Authors
- Philip B. Verghese (ORCID: https://orcid.org/0000-0003-4793-564X)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Rachel Studer (ORCID: https://orcid.org/0000-0002-4321-6210)
- Rebecca L. Koscik (ORCID: https://orcid.org/0000-0003-0025-744X)
- Lianlian Du
- Erin M. Jonaitis (ORCID: https://orcid.org/0009-0004-5091-8255)
- Tim West (ORCID: https://orcid.org/0000-0003-3267-8249)
- Karly Alex Cody (ORCID: https://orcid.org/0000-0001-5996-2560)
- Matthew R. Meyer (ORCID: https://orcid.org/0000-0002-4919-6927)
- Joel B. Braunstein (ORCID: https://orcid.org/0000-0002-1155-0206)
- Kevin E. Yarasheski (ORCID: https://orcid.org/0000-0001-5436-2451)
- Nathaniel A. Chin (ORCID: https://orcid.org/0000-0001-8008-9356)
- Kris Kirmess
- Sterling C. Johnson (ORCID: https://orcid.org/0000-0002-8501-545X)
- Bradley T. Christian (ORCID: https://orcid.org/0000-0002-9653-559X)
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3298-6324)
Institutions
- University of Wisconsin–Madison (US)
- C2N Diagnostics (United States) (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.14570
- Citations
- 6
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- Alzheimer's Drug Discovery Foundation
- BrightFocus Foundation
- University of Wisconsin-Madison
- National Institutes of Health
- Institute for Clinical and Translational Research, University of Wisconsin, Madison
- Eunice Kennedy Shriver National Institute of Child Health and Human Development