Effect of Wuzhi Capsule (WZC) on the Pharmacokinetics of Tacrolimus in Renal Transplantation Recipients
This study demonstrated that simultaneous administration of WZC had notable effects on the pharmacokinetics of tacrolimus and bioactive lignans in renal transplantation patients. The developed method proved to be reliable and sensitive for determining the whole blood concentrations of tacrolimus and WZC, making it suitable for pharmacokinetic studies in transplant patients.
Authors
- Jingwen Zhai
- Weiyue Zhang (ORCID: https://orcid.org/0000-0001-8370-0421)
- Shu Han (ORCID: https://orcid.org/0000-0002-7800-2394)
- Ruidong Wang
- Wei Wang (ORCID: https://orcid.org/0000-0001-5909-0205)
- Hong Liu (ORCID: https://orcid.org/0000-0002-7320-0260)
- Lin Li (ORCID: https://orcid.org/0000-0002-3111-5965)
- Jiani Chen (ORCID: https://orcid.org/0000-0002-0408-1798)
- Hua Wei (ORCID: https://orcid.org/0000-0002-3852-7276)
- Shiyi Liu
Institutions
- Beijing University of Chinese Medicine (CN)
- Second Military Medical University (CN)
- Shanghai Changzheng Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Current Drug Metabolism
- Published
- 2025-03-20
- DOI
- https://doi.org/10.2174/0113892002320686250310054152
- Citations
- 1
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.56