Mucus Barrier Weakens the Inhibitory Activity of Pyrogallol‐Based Polyphenols Against α‐Glucosidase
The mucus barrier weakens the inhibitory activity of pyrogallol-based polyphenols against α-glucosidase. Hence, overcoming the mucus barrier is a promising strategy to improve the regulation of pyrogallol-based polyphenols against postprandial hyperglycemia in vivo, which helps them to become novel α-glucosidase inhibitors in the clinic.
Authors
- Ziyang Deng (ORCID: https://orcid.org/0009-0005-4834-5088)
- Haibo Pan (ORCID: https://orcid.org/0000-0002-1695-4998)
- Shiguo Chen (ORCID: https://orcid.org/0000-0002-6439-7735)
- Xingqian Ye
- Yunxuan Li (ORCID: https://orcid.org/0000-0002-0738-5383)
- Laiming Zhang (ORCID: https://orcid.org/0000-0002-3848-5352)
- Yì Wáng (ORCID: https://orcid.org/0000-0002-3676-9183)
- Shuyun Lan (ORCID: https://orcid.org/0009-0005-4297-2849)
Institutions
- Zhongyuan University of Technology (CN)
- Zhejiang University of Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Molecular Nutrition & Food Research
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1002/mnfr.202400838
- Primary Topic
- Natural Antidiabetic Agents Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China