Systemic Lupus Erythematosus Stimulates Chondrocyte Pyroptosis to Aggravate Arthritis via Suppression of NRF-2/KEAP-1 and NF-κB Pathway
Collectively, our findings underscore the mechanistic connection between chondrocyte pyroptosis and arthritis exacerbation in SLE, suggesting potential therapeutic targets for mitigating arthritis progression in the context of SLE.
Authors
- Helou Zhang (ORCID: https://orcid.org/0000-0002-6891-1981)
- Yu Du (ORCID: https://orcid.org/0000-0002-6837-1567)
- Hongting Jin
- Hongfeng Ruan (ORCID: https://orcid.org/0000-0001-8868-9313)
- Taotao Xu (ORCID: https://orcid.org/0000-0002-2697-1484)
- Fangda Fu
- Changfeng Hu (ORCID: https://orcid.org/0000-0002-1666-6865)
- Tingting Lang (ORCID: https://orcid.org/0000-0002-9112-3270)
- Peijian Tong (ORCID: https://orcid.org/0000-0003-1647-1934)
- Chengliang Wu (ORCID: https://orcid.org/0000-0002-1741-8345)
- Shuchao Shen
- X. Fang
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/jir.s502800
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Zhejiang Chinese Medical University
- Natural Science Foundation of Zhejiang Province