Mediterranean vs. Western diet effects on the primate cerebral cortical pre‐synaptic proteome: Relationships with the transcriptome and multi‐system phenotypes
Mediterranean and Western diets differentially altered the cortical presynaptic proteome, which is strongly associated with neurodegeneration and cognitive decline. Presynaptic proteomic markers were predicted by transcriptomic profiles in the adjacent cortex, and by multi-system anatomical, physiologic, and behavioral phenotypes. The data demonstrate that brain phenotypes and brain-body interactions are influenced by common dietary patterns, suggesting that improving diet quality may be an effective means to maintain brain health.
Authors
- Geetha Saarunya
- Thanaphong Phongpreecha (ORCID: https://orcid.org/0000-0001-9245-6686)
- Suzanne Craft (ORCID: https://orcid.org/0000-0003-0591-8657)
- Amalia Perna (ORCID: https://orcid.org/0000-0001-5569-8512)
- Jacob D. Negrey (ORCID: https://orcid.org/0000-0001-7355-0319)
- Nima Aghaeepour (ORCID: https://orcid.org/0000-0002-6117-8764)
- Kathleen S. Montine (ORCID: https://orcid.org/0000-0003-2110-8363)
- Carol A. Shively (ORCID: https://orcid.org/0000-0002-1536-2288)
- Sayane Shome
- Brett M. Frye (ORCID: https://orcid.org/0000-0001-8818-063X)
- Eloïse Berson (ORCID: https://orcid.org/0000-0003-1046-125X)
- Chandresh R. Gajera (ORCID: https://orcid.org/0000-0002-4638-2097)
- Thomas C. Register (ORCID: https://orcid.org/0000-0002-4078-0166)
Institutions
- Emory and Henry College (US)
- Stanford Medicine (US)
- Wake Forest University (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.70041
- Citations
- 1
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- National Institutes of Health
- Wu Tsai Neurosciences Institute, Stanford University