AQP1 Affects Necroptosis by Targeting RIPK1 in Endothelial Cells of Atherosclerosis
Our study identified that AQP1 suppresses atherosclerotic necroptosis by inhibiting the expression of RIPK3 and MLKL in ECs which might indicates that AQP1 plays a role in atherosclerosis. This new mechanism contributes to improving the diagnostic, prognostic, and therapeutic outcomes of atherosclerosis.
Authors
- Keyi Fan (ORCID: https://orcid.org/0000-0002-1820-9107)
- Yusi Yang (ORCID: https://orcid.org/0000-0002-9539-8968)
- Xinyang Yue (ORCID: https://orcid.org/0009-0005-8636-2575)
- Ping Wang (ORCID: https://orcid.org/0000-0002-1491-9726)
- Lin Zheng (ORCID: https://orcid.org/0000-0001-7771-5483)
- Honglin Dong (ORCID: https://orcid.org/0000-0003-3345-9080)
- Haonan Zhou
- Jie Liu (ORCID: https://orcid.org/0000-0002-6862-4085)
Institutions
- Hebei Medical University (CN)
- Shanxi Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Vascular Health and Risk Management
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/vhrm.s487327
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00