Evaluation of safety, immunogenicity, and efficacy of inactivated reverse-genetics-based H5N8 highly pathogenic avian influenza virus vaccine with various adjuvants via parenteral and mucosal routes in chickens
These results underscore the importance of both the adjuvants and delivery route to maximize HPAI vaccine efficacy. This presented system could thereby be used to develop potent and DIVA-compatible vaccines to enhance biosecurity and disease management in regions affected by endemic HPAI.
Authors
- Leila Yelchibayeva
- Olaitan Comfort Shekoni
- Gleb Fomin (ORCID: https://orcid.org/0000-0002-3242-3898)
- Kaissar Tabynov (ORCID: https://orcid.org/0000-0001-5823-1280)
- Zauresh B. Zhumadilova (ORCID: https://orcid.org/0009-0002-7489-2737)
- Nikolai Petrovsky (ORCID: https://orcid.org/0000-0002-1580-5245)
- Gourapura J. Renukaradhya (ORCID: https://orcid.org/0000-0003-2861-180X)
- Kuantay Zharmambet
- Aidana Kuanyshbek
Institutions
- Kazakh Research Institute of Plant Protection and Quarantine (KZ)
- Vaxine (Australia) (AU)
- Kazakh National Agrarian Research University (KZ)
- The Ohio State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1539492
- Citations
- 4
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.42