Antioxidant activity and gel formulation of Areca catechu fractionation

Background: Areca catechu seeds are a commodity quite common in the Sumatra area and easy to find in Jambi Province.Gel preparations are one form of preparation that can be comfortably applied to the skin's surface.The gel base is more than 60% water, making this type of preparation convenient to use as an option for cosmetic and medicinal purposes.Method: The research was carried out experimentally, and it included plant collection, plant identification, phytochemical screening, fraction making, gel preparation formulation, antioxidant activity test using the DPPH method, and analysis of chemical components in the best fraction. Results:The IC50 values obtained in ethanol extracts, n-hexane fractions, ethyl acetate, nbutanol, and residual water were 31.1370;140,4038; 44,6600; 25,6350; 30,9579 g/mL sequential.In the formulation of the gel formulation of the n-butanol fraction, the IC50 value at F1, F2, F3, F4, F5 is 221,9660; 73,4390; 66,1160; 114,8390; 99.3540 g/mL sequential.Seven compounds were detected in the analysis of chemical components with HPLC-MS/MS instruments. Conclusion:The n-butanol fraction with the best extract part in Areca catechu and F3 is the best combination of gel formulation.