Relationships between hypometabolism and both β‐amyloid and tau PET in corticobasal syndrome
Amyloid (A) and tau PET (T) status can be used to stratify CBS patients. A+T+ CBS patients show more hypometabolism in temporo-parieto-occipital cortices. Medial temporal metabolism (typical AD pattern) is similar across AT groups. Parieto-occipital cortices should be assessed when investigating AT pathology in CBS. Amyloid and tau positivity contribute synergistically to hypometabolism and asymmetry in CBS.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Jonathan Graff‐Radford (ORCID: https://orcid.org/0000-0003-2770-0691)
- Farwa Ali (ORCID: https://orcid.org/0000-0001-6060-3995)
- Keith A. Josephs (ORCID: https://orcid.org/0000-0003-2930-8634)
- Federica Agosta (ORCID: https://orcid.org/0000-0003-3121-4979)
- Mary M. Machulda (ORCID: https://orcid.org/0000-0003-4834-5967)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Christopher G. Schwarz (ORCID: https://orcid.org/0000-0002-1466-8357)
- Yehkyoung C. Stephens (ORCID: https://orcid.org/0000-0003-0761-3283)
- Alma Ghirelli (ORCID: https://orcid.org/0000-0001-8440-1036)
- Jennifer L. Whitwell (ORCID: https://orcid.org/0000-0001-6914-1563)
- Austin W. Goodrich (ORCID: https://orcid.org/0009-0008-5596-0873)
Institutions
- Mayo Clinic (US)
- Vita-Salute San Raffaele University (IT)
- Mayo Clinic in Florida (US)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.70018
- Citations
- 3
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- National Institutes of Health