Interactions between menopause and high‐fat diet on cognition and pathology in a mouse model of Alzheimer's disease
The combination of menopause and HF diet led to early onset of cognitive impairment. HF diet increased amyloid pathology in the hippocampus. Menopause led to an increase in microglia density and a decrease in myelin in the corpus callosum. Menopause altered hippocampal neurogenesis in a diet-dependent manner.
Authors
- Abigail E. Salinero (ORCID: https://orcid.org/0000-0003-2886-1307)
- Charly Abi‐Ghanem (ORCID: https://orcid.org/0000-0003-3404-336X)
- Rachel M. Smith (ORCID: https://orcid.org/0000-0002-8256-5456)
- Christina A. Thrasher
- M. Batchelder
- Kristen L. Zuloaga (ORCID: https://orcid.org/0000-0002-5395-7362)
- Richard D. Kelly (ORCID: https://orcid.org/0000-0002-5150-1927)
- Damian G. Zuloaga (ORCID: https://orcid.org/0000-0002-2429-079X)
- M.-X. Wang
- Sally Temple (ORCID: https://orcid.org/0000-0001-7301-783X)
- Emily Groom
- Jennifer J Lafrican (ORCID: https://orcid.org/0009-0000-0087-8778)
- Aaron S. Paul
- Caitlin G. Valerian
Institutions
- University at Albany, State University of New York (US)
- Neural Stem Cell Institute (US)
- Albany Medical Center Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.70026
- Citations
- 8
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.36
Funders
- Alzheimer's Association
- American Heart Association
- BrightFocus Foundation
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke