Preparation of La2(WO4)3/CuWO4 composite nanomaterials with enhanced sonodynamic anti-glioma activity
The results showed that compared with La<sub>2</sub>(WO<sub>4</sub>)<sub>3</sub> and CuWO<sub>4</sub>, La<sub>2</sub>(WO<sub>4</sub>)<sub>3</sub>/CuWO<sub>4</sub> composite had better sonodynamic antitumor activity, and LC-10 had good biosafety at concentrations below 50 μg/mL. After La<sub>2</sub>(WO<sub>4</sub>)<sub>3</sub> and CuWO<sub>4</sub> formed La<sub>2</sub>(WO<sub>4</sub>)<sub>3</sub>/CuWO<sub>4</sub> composite, the recombination of electron-hole (<i>e</i> <sup>-</sup>-<i>h</i> <sup>+</sup>) pairs were effectively inhibited, and more strongly oxidizing ROS was produced, inducing apoptosis of u251 glioma cells. In which, singlet oxygen (<sup>1</sup>O<sub>2</sub>) and hydroxyl radical (·OH), especially the production of ⋅OH, played an important role in the La<sub>2</sub>(WO<sub>4</sub>)<sub>3</sub>/CuWO<sub>4</sub> composite mediated SDT antitumor process. The results of this study would offer a foundation for the design of CuWO<sub>4</sub> base nano-sonosensitizers and its further clinical application in SDT antitumor. In addition, it also provided a new strategy for the design and development of novel nano-sonosensitizers with excellent sonodynamic activity.
Authors
- Ye-Fu Liu
- Fang-Yu Liu (ORCID: https://orcid.org/0000-0002-8403-208X)
- Xin Wang (ORCID: https://orcid.org/0000-0003-4099-4268)
Institutions
- Liaoning University (CN)
- Liaoning University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
- Liaoning Cancer Hospital & Institute (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fbioe.2025.1566946
- Citations
- 1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.67