The Impact of Valproic Acid on Microbiota in a Mouse Model of Autism Spectrum Disorder

The present study provides evidence that VPA exposure during early development can induce ASD-like behaviors in mice, along with significant changes in the composition of the microbiota. These findings underscore the complex interplay between environmental factors, such as VPA, and the microbiota in the pathophysiology of ASD. The study lays the groundwork for future research aimed at developing targeted interventions to mitigate the symptoms of ASD and other neuropsychiatric disorders, potentially through modulating the microbiota-gut-brain axis.