Neutrophils negatively control IL-17A-producing γδ T cell frequencies in a contact-dependent manner under physiological conditions
This present study demonstrates that neutrophils negatively regulate IL-17 producing γδ T cells under physiological conditions. Given that IL-17A is a critical cytokine for the recruitment of neutrophils to peripheral tissues, our study suggests that the crosstalk between neutrophils and IL-17A producing γδ T cells is a crucial mechanism for maintaining immune homeostasis under physiological conditions.
Authors
- Xiaoyang Yue (ORCID: https://orcid.org/0000-0002-8571-7048)
- Brigitte Kasper (ORCID: https://orcid.org/0000-0002-0320-9614)
- Joseph T. Opferman (ORCID: https://orcid.org/0000-0002-1147-5621)
- Sebastian Marwitz (ORCID: https://orcid.org/0000-0003-4920-5552)
- Jochen Behrends (ORCID: https://orcid.org/0000-0002-0648-8911)
- Xinhua Yu (ORCID: https://orcid.org/0000-0003-2392-3740)
- Junie D. Tchudjin Magatsin
- Frank Petersen (ORCID: https://orcid.org/0000-0001-9847-8800)
- Torsten Goldmann (ORCID: https://orcid.org/0000-0002-1621-560X)
Institutions
- St. Jude Children's Research Hospital (US)
- Guangxi Medical University (CN)
- Research Center Borstel - Leibniz Lung Center (DE)
- German Center for Lung Research (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1542191
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00