Clinical outcomes and relapse patterns in pediatric acute leukemia patients undergoing hematopoietic cell transplantation: a multicenter Brazilian experience
These findings underscore the elevated relapse risk associated with advanced disease status, positive pre-HCT MRD, and mixed donor chimerism post-transplant. Future interventions should prioritize improving diagnostic capabilities, expanding access to modern treatment protocols, and facilitating early referral to transplant centers, particularly for aggressive disease presentations.
Authors
- Gisele Loth (ORCID: https://orcid.org/0000-0003-2378-5026)
- Carmem Bonfim (ORCID: https://orcid.org/0000-0003-0343-2610)
- Adriana Lima Mello (ORCID: https://orcid.org/0000-0002-1971-9299)
- Fernanda Moreira de Lara Benini
- M.N. Gandur Quiroga
- Simone Pereira Lermontov (ORCID: https://orcid.org/0000-0002-3518-4191)
- Samantha Nichele (ORCID: https://orcid.org/0000-0003-3857-2306)
- Joanna Trennepohl (ORCID: https://orcid.org/0000-0002-5080-9364)
- Rita de Cássia Barbosa da Silva Tavares (ORCID: https://orcid.org/0000-0002-9050-7918)
- Cilmara Kuwahara
- Alberto Cardoso Martins Lima (ORCID: https://orcid.org/0000-0002-7248-7060)
- Polliany Roberta Dorini Pelegrina (ORCID: https://orcid.org/0009-0006-7831-7288)
- R. Muratori (ORCID: https://orcid.org/0000-0001-5131-9853)
- Adriana Koliski (ORCID: https://orcid.org/0000-0001-7521-8766)
- Margareth Kleina Feitosa
- Rebeca Toassa Gomes
- Vivian Cristina da Silva (ORCID: https://orcid.org/0009-0006-7343-6042)
- Carolina Peixoto (ORCID: https://orcid.org/0000-0002-7958-850X)
- L. Gouvea
- Ana Paula de Azambuja (ORCID: https://orcid.org/0000-0001-9884-4735)
- Juliana Bach
Institutions
- Hospital Erasto Gaertner (BR)
- Hospital Nossa Senhora das Graças (BR)
- Hospital de Clínicas Universidade Federal do Paraná (BR)
- Instituto Nacional de Câncer - INCA (BR)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fped.2025.1573334
- Citations
- 3
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 5.31