Immune Checkpoint Inhibitor Therapy for Aggressive Pituitary Neuroendocrine Tumors
This study demonstrates the safety and feasibility of ICI treatment in aggressive PitNETs. We also identified MMRd and temozolomide hypermutation as potential biomarkers of response to ICI. Overall, our data suggest that ICIs might provide an additional treatment option for PitNET; this should be evaluated more broadly in future studies.
Authors
- Soma Sengupta (ORCID: https://orcid.org/0000-0003-4577-1397)
- Andrew Lin (ORCID: https://orcid.org/0000-0003-0659-261X)
- Eliza B. Geer (ORCID: https://orcid.org/0000-0003-3722-1889)
- Robert J. Young (ORCID: https://orcid.org/0000-0001-7003-3017)
- Anna F. Piotrowski (ORCID: https://orcid.org/0000-0003-0058-8476)
- Odelia Cooper (ORCID: https://orcid.org/0000-0001-5955-8242)
- Ingo K. Mellinghoff (ORCID: https://orcid.org/0000-0002-4347-8149)
- Igor T. Gavrilovic (ORCID: https://orcid.org/0000-0001-9104-6132)
- Mark T.A. Donoghue (ORCID: https://orcid.org/0000-0003-4538-6069)
- Bernard Goichot (ORCID: https://orcid.org/0000-0001-7794-1683)
- Rajiv Magge (ORCID: https://orcid.org/0000-0002-2870-6895)
- Thomas Kaley (ORCID: https://orcid.org/0000-0002-2540-8518)
- Marc K. Rosenblum (ORCID: https://orcid.org/0000-0002-0530-0155)
- Vasilisa A. Rudneva (ORCID: https://orcid.org/0000-0002-4340-9311)
- Nazanin Majd (ORCID: https://orcid.org/0000-0001-6451-544X)
- Viviane Tabar (ORCID: https://orcid.org/0000-0002-1284-1670)
- Adam Newton
Institutions
- University of North Carolina at Chapel Hill (US)
- Cedars-Sinai Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Cornell University (US)
- Hôpitaux Universitaires de Strasbourg (FR)
- Molecular Oncology (United States) (US)
- UNC Lineberger Comprehensive Cancer Center
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1210/clinem/dgaf178
- Citations
- 8
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.36