An Expandable Brain‐Machine Interface Enabled by Origami Materials and Structures for Tracking Epileptic Traveling Waves
Tracking neural activities across multiple brain regions remains a daunting challenge due to the non-negligible skull injuries during implantations of large-area electrocorticography (ECoG) grids and the limited spatial accessibility of conventional rectilinear depth probes. Here, a multiregion Brain-machine Interface (BMI) is proposed comprising an expandable bio-inspired origami ECoG electrode covering cortical areas larger than the cranial window, and an expandable origami depth probe capable of reaching multiple deep brain regions beyond a single implantation axis. Using the proposed BMI, it is observed that, in rat models of focal seizures, cortical multiband epileptiform activities mainly manifest as expanding traveling waves outward from a cortical source.
Authors
- Tian‐Lu Sheng
- Maoyi Xie (ORCID: https://orcid.org/0009-0001-4496-5037)
- Nianzhen Du
- Lianqing Liu (ORCID: https://orcid.org/0000-0002-2271-5870)
- Wenqian Liu (ORCID: https://orcid.org/0000-0003-2760-7446)
- Yiyu Yao (ORCID: https://orcid.org/0000-0001-6502-6226)
- Xiaoqiu Shao (ORCID: https://orcid.org/0000-0001-5798-7115)
- Meng‐sha Huang
- Xize Gao (ORCID: https://orcid.org/0000-0003-0717-3353)
- M.M. Zhang (ORCID: https://orcid.org/0009-0008-9358-9972)
- Jing Xu (ORCID: https://orcid.org/0000-0002-2997-2351)
- Guo Yong (ORCID: https://orcid.org/0000-0002-7361-2441)
- Xiaolong Wang (ORCID: https://orcid.org/0000-0003-4210-840X)
- Jingwei Li (ORCID: https://orcid.org/0009-0007-8696-5477)
- Yilong Wang (ORCID: https://orcid.org/0000-0003-2725-2788)
- Lingyi Zheng
- S.P. Wen
Institutions
- Fujian Medical University (CN)
- Shenyang Institute of Automation (CN)
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Advanced Healthcare Materials
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1002/adhm.202404947
- Citations
- 2
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- National Key Research and Development Program of China