Application and Synthesis of a New Hybrid Heterocyclic Derivative with Antioxidant Evaluation

New hydrazinecarboximidamide derivatives were successfully synthesized with excellent yields.These compounds have been proven to be potent inhibitors of acetylcholinesterase and tubulin, and they also exhibit significant antioxidant effects.Furthermore, an ADMET study was conducted, which suggests that these compounds not only possess the potential to cross the blood-brain barrier.These findings allow us to consider this product as a promising candidate for future medicinal development, particularly in the treatment of neurodegenerative diseases and cancer.

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Published
2024-11-14
DOI
https://doi.org/10.3390/ecsoc-28-20125
Primary Topic
Synthesis and biological activity
Type
article
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article

Application and Synthesis of a New Hybrid Heterocyclic Derivative with Antioxidant Evaluation

Selma Rabhi, A. Belkacem, Roumaissa Djaafarou
Synthesis and biological activity
article

Application and Synthesis of a New Hybrid Heterocyclic Derivative with Antioxidant Evaluation

Selma Rabhi, A. Belkacem, Roumaissa Djaafarou
article en

Abstract

New hydrazinecarboximidamide derivatives were successfully synthesized with excellent yields.These compounds have been proven to be potent inhibitors of acetylcholinesterase and tubulin, and they also exhibit significant antioxidant effects.Furthermore, an ADMET study was conducted, which suggests that these compounds not only possess the potential to cross the blood-brain barrier.These findings allow us to consider this product as a promising candidate for future medicinal development, particularly in the treatment of neurodegenerative diseases and cancer.

University Frères Mentouri Constantine 1 (DZ)
Zero hunger
Openalex Percentile: Top 81%
Synthesis and biological activity
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