Application and Synthesis of a New Hybrid Heterocyclic Derivative with Antioxidant Evaluation
New hydrazinecarboximidamide derivatives were successfully synthesized with excellent yields.These compounds have been proven to be potent inhibitors of acetylcholinesterase and tubulin, and they also exhibit significant antioxidant effects.Furthermore, an ADMET study was conducted, which suggests that these compounds not only possess the potential to cross the blood-brain barrier.These findings allow us to consider this product as a promising candidate for future medicinal development, particularly in the treatment of neurodegenerative diseases and cancer.
Authors
- Selma Rabhi (ORCID: https://orcid.org/0009-0009-9676-1253)
- A. Belkacem
- Roumaissa Djaafarou
Institutions
- University Frères Mentouri Constantine 1 (DZ)
Publication Details
- Published
- 2024-11-14
- DOI
- https://doi.org/10.3390/ecsoc-28-20125
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00