[MSB-32] Comparison of Platelet Changes Between Mini-Extracorporeal Circulation and Conventional Cardiopulmonary Bypass

Objective: This study aimed to evaluate the efficacy of mini-extracorporeal circulation (MECC) in reducing platelet damage compared to conventional cardiopulmonary bypass (CCPB). Methods: Sixty-seven patients (52 males, 15 females; mean age: 63.04±8.08 years) who underwent isolated coronary artery bypass grafting between August 2022 and February 2024 were retrospectively analyzed. The patients were divided into two groups: CCPB (n=37) and MECC (n=30). Demographic data, comorbidities, operative variables, laboratory values, and drainage volume data were collected from electronic medical records. Results: No significant difference in median drainage volume was found between the MECC group and the CCPB group (300 mL vs. 350 mL; p=0.178). There was no statistically significant difference between the groups regarding cardiopulmonary bypass time and cross-clamp time (p=0.160 and p=0.158, respectively). There was no significant difference between the groups in preoperative and postoperative platelet counts (p=0.687 and p=0.335, respectively). The mean decrease in postoperative platelet count was 0.89±3.99% in the MECC group and 13±2.98% in the CCPB group. The difference in platelet count change between the groups was found to be statistically significant (p=0.028). Conclusion: This study suggests that mini extracorporeal circulation significantly reduces postoperative platelet decline compared to conventional cardiopulmonary bypass, indicating its potential to better preserve platelet levels.