Targeting HSF1-TLR9 Axis: Celastrol as a Potential Therapeutic for Liver Injury in Traumatic Hemorrhagic Shock
This study demonstrates that Cel attenuates THS-induced liver injury by positively regulating <i>HSF1</i> so as to inhibit the expression of <i>TLR9</i>.
Authors
- Jia-Ji Zhu (ORCID: https://orcid.org/0000-0002-1328-356X)
- Y Zhan (ORCID: https://orcid.org/0009-0003-2339-7581)
- Xiaoyun Sun (ORCID: https://orcid.org/0000-0002-1622-5840)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Yiwu Science and Technology Research Institute (CN)
- The Eighth Hospital of Xi'an (CN)
Publication Details
- Journal
- Discovery Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.24976/discov.med.202537194.42
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00