Chemokine (C-C Motif) Ligand 2 Expressing Adventitial Fibroblast Expansion During Loeys-Dietz Syndrome Aortic Aneurysm Formation
Despite phenotypic similarities in aneurysm formation, the dominant cellular and molecular mechanism of Marfan syndrome and LDS aneurysms are distinct. LDS mouse and human adventitial fibroblasts transcriptomically modulate into a proinflammatory state. Adventitial fibroblasts, in addition to SMCs, are another important pathological cell population during LDS aneurysm formation to consider for targeted therapy to potentially impede LDS aneurysm formation.
Authors
- Gerald J. Berry (ORCID: https://orcid.org/0000-0002-6176-2629)
- William T. Jackson (ORCID: https://orcid.org/0000-0002-9832-0584)
- Michael P. Fischbein (ORCID: https://orcid.org/0000-0002-0638-2025)
- Elena Gallo MacFarlane (ORCID: https://orcid.org/0000-0001-5677-6842)
- Thomas Quertermous (ORCID: https://orcid.org/0000-0002-7645-9067)
- Sho Kusadokoro (ORCID: https://orcid.org/0000-0002-4944-6092)
- William Hiesinger (ORCID: https://orcid.org/0000-0002-3548-2578)
- Albert J Pedroza (ORCID: https://orcid.org/0000-0001-5291-5980)
- Casey Gilles (ORCID: https://orcid.org/0009-0008-3527-629X)
- Wenduo Gu (ORCID: https://orcid.org/0000-0002-3859-3150)
- Rohan Shad (ORCID: https://orcid.org/0000-0002-0453-9041)
- Jennifer L. Kim (ORCID: https://orcid.org/0000-0002-2313-2685)
- Alex R. Dalal (ORCID: https://orcid.org/0000-0002-9993-3817)
- Paul P. Cheng (ORCID: https://orcid.org/0000-0003-3429-2702)
- Olivia Mitchel
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1161/atvbaha.124.322069
- Citations
- 4
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.07