Three bioactive dibenzocyclooctadiene lignans from the fruits of <i>Kadsura coccinea</i>
Three new dibenzocyclooctadiene lignans, namely, kadcolignan H-J (<b>1</b>-<b>3</b>), were isolated from the ethanol extract of <i>Kadsura coccinea</i> fruits. Their molecular structures, including absolute configurations, were elucidated through comprehensive spectroscopic analyses. The hepatoprotective effects of kadcolignan H-J (<b>1</b>-<b>3)</b> were subsequently evaluated. Both kadcolignan H (<b>1)</b> and kadcolignan J <b>(3)</b> demonstrated inhibitory effects on triglyceride and total cholesterol levels, whereas all isolated compounds effectively reduced the levels of free fatty acids-induced reactive oxygen species in HepG2 cells.
Authors
- An Jin
- Wenming Wu (ORCID: https://orcid.org/0009-0008-8770-6861)
- Zhenxing Wang (ORCID: https://orcid.org/0000-0003-2199-4684)
- Chao Chen (ORCID: https://orcid.org/0000-0001-9533-7340)
- Jian Liu (ORCID: https://orcid.org/0000-0002-3220-1240)
Institutions
- Nanchang University (CN)
- Hunan University (CN)
- Hunan Provincial Center for Disease Control and Prevention (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1080/14786419.2025.2479247
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province