Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice
IBC effectively ameliorates AD pathology through autophagy-mediated clearance of Aβ and suppressing neuroinflammation in 5x-FAD mice.
Authors
- Priya Wazir
- Syed Mudassir Ali
- Parul Khajuria
- Sanghapal D. Sawant (ORCID: https://orcid.org/0000-0002-6224-3214)
- Alpa Sharma
- Dilpreet Kour (ORCID: https://orcid.org/0009-0006-4865-2376)
- P. Ramajayan
- Ajay Kumar (ORCID: https://orcid.org/0000-0002-3889-3049)
- Utpal Nandi (ORCID: https://orcid.org/0000-0002-7868-0240)
- Zabeer Ahmed (ORCID: https://orcid.org/0000-0003-4162-8286)
- Kuhu Sharma
- Ankita Sharma (ORCID: https://orcid.org/0000-0002-6983-0235)
Institutions
- National Chemical Laboratory (IN)
- Indian Institute of Integrative Medicine (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fphar.2025.1525364
- Citations
- 3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49