A multi-omics reciprocal analysis for characterization of bacterial metabolism
We described BRA006 genomic content and structure by comparing Illumina and Oxford Nanopore MinION sequencing approaches. Digital DNA:DNA hybridization (dDDH) taxonomically assigned BRA006 as a potential new species of the Micromonospora genus. Starting from LC-ESI(+)-HRMS/MS data, and mapping the annotated enzymes and metabolites belonging to the same pathways, our integrative analysis allowed us to correlate the compound Brevianamide F to a new BGC, previously assigned to other function.
Authors
- Guilherme Marcelino Viana de Siqueira (ORCID: https://orcid.org/0000-0002-3645-6363)
- Lucas Sousa Neves Andrade (ORCID: https://orcid.org/0000-0002-5003-1599)
- Gabriel Padilla (ORCID: https://orcid.org/0000-0001-8086-3065)
- Daniela Barretto Barbosa Trivella (ORCID: https://orcid.org/0000-0002-7505-2345)
- Elthon G. Ferreira (ORCID: https://orcid.org/0000-0001-8381-7849)
- Tiago Cabral Borelli (ORCID: https://orcid.org/0000-0002-5705-1808)
- Gabriel Santos Arini (ORCID: https://orcid.org/0000-0001-9948-2545)
- Alberto Gil-de-la-Fuente (ORCID: https://orcid.org/0000-0002-5951-1601)
- Mingxun Wang (ORCID: https://orcid.org/0000-0001-7647-6097)
- Ricardo Silva (ORCID: https://orcid.org/0000-0001-6378-0479)
- Matheus Pedrino (ORCID: https://orcid.org/0000-0003-0687-4692)
- Norberto Peporine Lopes (ORCID: https://orcid.org/0000-0002-8159-3658)
- María‐Eugenia Guazzaroni (ORCID: https://orcid.org/0000-0002-4657-3731)
- Leandro M. Garrido (ORCID: https://orcid.org/0000-0001-5311-1183)
- Rafael de Felício (ORCID: https://orcid.org/0000-0002-3698-940X)
- Letícia V. Costa‐Lotufo (ORCID: https://orcid.org/0000-0003-1861-5153)
- Franciene Rabiço
- Luiz Gabriel Mencucini (ORCID: https://orcid.org/0000-0002-5773-5329)
- Paula Rezende-Teixeira
- Henrique Tsuji (ORCID: https://orcid.org/0000-0002-9696-8141)
Institutions
- University of California, Riverside (US)
- Universidad San Pablo CEU (ES)
- Universidade de São Paulo (BR)
- Brazilian Center for Research in Energy and Materials (BR)
- Brazilian Biosciences National Laboratory (BR)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fmolb.2025.1515276
- Citations
- 1
- Primary Topic
- Genomics and Phylogenetic Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81