Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration
Metformin inhibits pathological retinal neovascularization but promotes fibrosis in experimental nAMD. These results provide evidence and highlight important considerations for the clinical use of metformin in different stages of nAMD.
Authors
- Zuguo Liu (ORCID: https://orcid.org/0000-0002-1737-5736)
- Liang Xu (ORCID: https://orcid.org/0000-0001-8946-8280)
- Yuxin Miao (ORCID: https://orcid.org/0000-0001-8419-6511)
- Mingyan Wei
- Rongrong Zong
- Shiya Huang (ORCID: https://orcid.org/0000-0001-8677-5023)
- Xin Wang (ORCID: https://orcid.org/0000-0002-0322-8970)
- Xiao Dong Chen (ORCID: https://orcid.org/0000-0002-0150-0491)
- Xiang Lin (ORCID: https://orcid.org/0000-0002-5349-8928)
- Chen Qian (ORCID: https://orcid.org/0000-0003-4961-5076)
- Shiying Li (ORCID: https://orcid.org/0000-0001-9783-9520)
- Yuan Xu
Institutions
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Suizhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3389/fphar.2025.1547492
- Citations
- 2
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61