Differential pain perception among females with or without nonspecific chronic low back pain and comorbid insomnia: a quantitative sensory testing analysis

Sleep disturbance is a prevalent condition in individuals with chronic low back pain (CLBP). Despite a strong association between the 2 conditions, the potential mechanisms underlying the role of sleep disturbance in CLBP remain unclear. This case-control study aimed to examine pain perception among females with or without nonspecific CLBP and comorbid insomnia. One hundred females were recruited (mean age: 34.3 ± 11.4 years), with 25 individuals with concomitant CLBP and insomnia (CLBP+I), 25 with CLBP (CLBP+), 25 with insomnia (Insomnia+), and 25 healthy controls. All participants completed self-report questionnaires and quantitative sensory testing (QST). Our study found that CLBP+I exhibited lower mechanical pain and pressure pain thresholds (PPT) in both painful and nonpainful areas and impaired conditioned pain modulation (CPM) as compared to healthy controls. Similar findings were found in PPT at the back and CPM when compared to CLBP+. However, no significant differences were noted in thermal pain thresholds and temporal summation of pain across the 4 groups. Furthermore, CLBP+I and Insomnia+ displayed higher levels of functional disability, maladaptive beliefs, and negative mood than CLBP+ or healthy controls. There were significant increases in pain sensitivity to pressure stimuli, decreases in descending pain inhibitory effects, and higher levels of maladaptive psychological status in CLBP+I compared to CLBP+. These findings underscore the importance of incorporating sleep assessments as a routine practice in treating CLBP cases. Future studies are warranted to validate our findings in males, establish the diagnostic and prognostic value of QST, and probe the neurophysiological mechanisms in comorbid conditions.