Strain Elastography: A Non‐Invasive Modality for Extrathyroidal Extension Assessment in Papillary Thyroid Cancer
This study investigated the value of strain elastography (SE) in assessing extrathyroidal extension (ETE) in papillary thyroid cancer (PTC). A total of 277 PTC nodules from 245 patients were included. SE demonstrated higher consistency with pathology compared to US (Kappa value: 0.735 vs. 0.562, p = 0.000, respectively). SE also showed superior specificity (91.4% vs. 74.1%, p = 0.000) and accuracy (87.7% vs. 78.3%, p = 0.003) in diagnosing ETE. The area under the curve for SE was significantly higher than for US (0.865 vs. 0.798, p = 0.006). Age and calcification influenced SE's diagnostic performance. SE is a promising noninvasive tool for ETE assessment in PTC.
Authors
- Ronghua Yan
- Xingcheng Liu (ORCID: https://orcid.org/0000-0003-1836-2205)
- Shiwen Zhang (ORCID: https://orcid.org/0000-0001-7251-8544)
- Lingli Xiao (ORCID: https://orcid.org/0000-0002-5310-1951)
- Erjiao Xu (ORCID: https://orcid.org/0000-0001-6454-2026)
- Sainan Guan
- Huahui Liu (ORCID: https://orcid.org/0000-0002-9291-5616)
- Xiaodan Zhang (ORCID: https://orcid.org/0000-0002-2606-338X)
- Shuguang Liu (ORCID: https://orcid.org/0000-0002-8523-8741)
- Shuang Liang (ORCID: https://orcid.org/0000-0002-5250-1494)
- Liping Luo (ORCID: https://orcid.org/0000-0001-7070-7309)
- Zhou Xi
- Cai Hu
- Wanling Huang
Institutions
- Sun Yat-sen University (CN)
- Peking University Shenzhen Hospital (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Journal of Clinical Ultrasound
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1002/jcu.23970
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shenzhen Science and Technology Innovation Program
- Basic and Applied Basic Research Foundation of Guangdong Province