Estrogen via GPER downregulated HIF-1a and MIF expression, attenuated cardiac arrhythmias, and myocardial inflammation during hypobaric hypoxia
Estrogen regulates HIF-1α and MIF expression through the GPER during hypobaric hypoxia, suggesting a potential therapeutic pathway to mitigate maladaptive responses during high-altitude ascent.
Authors
- Prosperl Ivette Wowui (ORCID: https://orcid.org/0000-0003-4910-3046)
- Sharif M. Shaheen (ORCID: https://orcid.org/0000-0002-5966-7227)
- Marie Louise Ndzie Noah (ORCID: https://orcid.org/0000-0003-3262-7556)
- Joseph Adu‐Amankwaah (ORCID: https://orcid.org/0000-0003-2155-0864)
- Richard Mprah (ORCID: https://orcid.org/0000-0001-8762-5481)
- Tao Li (ORCID: https://orcid.org/0000-0002-9174-1271)
- Hong Sun (ORCID: https://orcid.org/0000-0003-2135-3107)
- Anastasia Wemaaatu Lamawura Kanoseh
- Diana Chulu
- Simon Kumah Yalley
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1186/s10020-025-01144-2
- Citations
- 4
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Priority Academic Program Development of Jiangsu Higher Education Institutions