p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitis
p53 is of intense interest as a potent tumour suppressor and compounds targeting the pathway have been developed and trialled as anti-cancer therapies. Our findings suggest that early activation of p53 is similarly protective against metabolic dysfunction-associated steatohepatitis and that redox control is an important mediator of this protection. Further studies evaluating the efficacy of proactive activation of p53 in the liver to prevent metabolic dysfunction-associated steatohepatitis, or administration of targeted antioxidants to augment p53 redox protection, could provide new treatment approaches for a condition with few approved therapies.
Authors
- Dale M. Watt (ORCID: https://orcid.org/0000-0002-0443-176X)
- Timothy J. Humpton (ORCID: https://orcid.org/0000-0002-8030-9539)
- Karen Blyth (ORCID: https://orcid.org/0000-0002-9304-439X)
- Eric C. Cheung (ORCID: https://orcid.org/0009-0002-4373-9502)
- Dimitris Athineos (ORCID: https://orcid.org/0000-0001-5298-7941)
- Karen H. Vousden (ORCID: https://orcid.org/0000-0002-7365-1766)
- Celine I Wittke (ORCID: https://orcid.org/0009-0009-5455-4002)
- Nicola Clements
- Vivienne Morrison (ORCID: https://orcid.org/0009-0009-1022-8969)
- Mark Hughes (ORCID: https://orcid.org/0000-0001-5754-3725)
- Liam Butler (ORCID: https://orcid.org/0009-0002-6461-3773)
Institutions
- Glasgow Caledonian University (GB)
- The Francis Crick Institute (GB)
- Cancer Research UK (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101397
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Glasgow Caledonian University
- Wellcome Trust
- Francis Crick Institute
- Department for Business, Energy and Industrial Strategy, UK Government
- Cancer Research UK
- British Heart Foundation
- Diabetes UK
- Academy of Medical Sciences
- Tenovus
- Medical Research Council
- European Research Council