Influence of imidazole functionalization on the properties of small molecule models of the LPMO active site
A series of small molecule Cu(II) complexes based on tridentate N<sub>3</sub> ligands relevant to the histidine brace of the active site of lytic polysaccharide monooxygenase were synthesized and characterized by X-ray crystallography and spectroscopic studies. In order to better understand the role of different structural features and to help bridge the differences between previously reported models, the methylation patterns, imidazole connectivity, linker nature, and type of heterocycle were systematically varied across the series. These modifications lead to important differences in the electrochemical properties of the complexes and their reactivity towards the oxidation of a model substrate.
Authors
- Koen Robeyns (ORCID: https://orcid.org/0000-0002-4763-4217)
- Gaël De Leener (ORCID: https://orcid.org/0000-0001-9428-9324)
- Michel Luhmer (ORCID: https://orcid.org/0000-0002-4089-6644)
- Ugo Gilbert
- Sarah Lam (ORCID: https://orcid.org/0000-0001-5201-8155)
- Michael L. Singleton (ORCID: https://orcid.org/0000-0002-4018-9595)
- Raphaël Robiette (ORCID: https://orcid.org/0000-0002-3449-565X)
- Maëlle Bottin
- Xiao Mu
- Martin Schoenauen
Institutions
- Université Libre de Bruxelles (BE)
- UCLouvain (BE)
Publication Details
- Journal
- Dalton Transactions
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4dt03424d
- Citations
- 1
- Primary Topic
- Lanthanide and Transition Metal Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.52
Funders
- Fonds De La Recherche Scientifique - FNRS
- China Scholarship Council
- Innoviris
- Horizon 2020 Framework Programme