Blood biomarkers differentiate AD‐related versus non‐AD‐related cognitive deficits
There is heterogeneity in the causes of cognitive decline in aging. AD-related blood biomarkers may help characterize these causes. Elevated p-tau217 was exclusively associated with poorer episodic memory. Elevated NfL was associated with poorer cognition in a broad range of domains. Blood biomarkers may help differentiate AD- and non-AD-related cognitive deficits.
Authors
- Kirk I. Erickson (ORCID: https://orcid.org/0000-0001-8736-981X)
- George Grove (ORCID: https://orcid.org/0000-0002-5043-139X)
- Xuemei Zeng (ORCID: https://orcid.org/0000-0003-4885-4788)
- Arthur Kramer (ORCID: https://orcid.org/0000-0002-1991-5046)
- Eric D. Vidoni (ORCID: https://orcid.org/0000-0001-5181-7131)
- Paul J. Kueck (ORCID: https://orcid.org/0000-0002-9102-2058)
- Edward McAuley (ORCID: https://orcid.org/0000-0002-4574-3292)
- Lauren E. Oberlin (ORCID: https://orcid.org/0000-0001-9553-8070)
- Marcos Olvera‐Rojas (ORCID: https://orcid.org/0000-0001-7922-1647)
- Jill K. Morris (ORCID: https://orcid.org/0000-0001-5911-4190)
- Anna L. Marsland (ORCID: https://orcid.org/0000-0001-8951-7513)
- Kelsey R. Sewell (ORCID: https://orcid.org/0000-0002-3859-5017)
- Anuradha Sehrawat (ORCID: https://orcid.org/0000-0002-7243-5447)
- Charles H. Hillman (ORCID: https://orcid.org/0000-0002-3722-5612)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Jeffrey Murray Burns (ORCID: https://orcid.org/0000-0001-7609-8954)
- M. Ilyas Kamboh (ORCID: https://orcid.org/0000-0002-3453-1438)
- Haiqing Huang (ORCID: https://orcid.org/0000-0002-8932-7995)
- Chaeryon Kang (ORCID: https://orcid.org/0000-0001-9442-8515)
- Tara K Lafferty
- Yijun Chen (ORCID: https://orcid.org/0000-0002-4920-152X)
- Lu Wan
Institutions
- Northeastern University (US)
- University of Kansas (US)
- University of Illinois Urbana-Champaign (US)
- University of Pittsburgh (US)
- Universidad de Granada (ES)
- Murdoch University (AU)
- Cornell University (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.14619
- Citations
- 11
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 16.18
Funders
- University of Kansas
- University of Pittsburgh
- National Institutes of Health