Exploratory analysis of the proteomic profile in plasma in adults with Down syndrome in the context of Alzheimer's disease
Inflammatory pathways are dysregulated in symptomatic versus asymptomatic DS. NFL and GFAP are confirmed as powerful biomarkers in DS with clinical and/or cognitive decline. Further circulating proteins were identified as potential blood biomarkers for symptomatic DS.
Authors
- Elisabeth Wlasich (ORCID: https://orcid.org/0009-0002-2733-7511)
- Francisco J. Martínez-Murcia (ORCID: https://orcid.org/0000-0001-8146-7056)
- Juan Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- J. M. Górriz (ORCID: https://orcid.org/0000-0001-7069-1714)
- Sandra Loosli
- Rocío Romero‐Zaliz (ORCID: https://orcid.org/0000-0003-4500-9781)
- Agnese Petrera (ORCID: https://orcid.org/0000-0002-0583-6195)
- Stefanie M. Hauck (ORCID: https://orcid.org/0000-0002-1630-6827)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Anna Stockbauer
- C. Jiménez-Mesa (ORCID: https://orcid.org/0000-0003-2494-2951)
- Sabrina Katzdobler (ORCID: https://orcid.org/0000-0002-3512-5984)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Georg Nübling
- Catharina Prix
- Olivia Wagemann (ORCID: https://orcid.org/0000-0003-3211-9105)
- Katja Sandkühler
Institutions
- Universidad de Granada (ES)
- German Center for Neurodegenerative Diseases (DE)
- Hospital de Sant Pau (ES)
- Helmholtz Zentrum München (DE)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Instituto Andaluz de Ciencias de la Tierra (ES)
- University Hospital of Zurich (CH)
- Munich Cluster for Systems Neurology (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.70040
- Citations
- 6
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 11.27
Funders
- Stiftung VERUM
- Alzheimer Forschung Initiative
- European Commission
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Generalitat de Catalunya
- Else Kröner-Fresenius-Stiftung
- Fundación Tatiana Pérez de Guzmán el Bueno
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- National Institutes of Health
- Horizon 2020 Framework Programme
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación