Genome-Wide Impact of Folic Acid on DNA Methylation and Gene Expression in Lupus Adipocytes: An In Vitro Study on Obesity

Folic acid treatment exerts distinct epigenetic and gene expression effects in adipocytes of SLE patients, modulated by obesity status. This weight-dependent response, marked by changes in pathways relevant to immune and metabolic function, highlights the need for further investigation into how nutrient-based interventions might support SLE management. From a clinical perspective, this study underscores the potential of targeted nutrient-based interventions to address immunometabolic dysfunctions in SLE patients. Further research could explore folic acid supplementation as a complementary approach to personalized treatment strategies, particularly for patients with obesity.

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Publication Details

Journal
Nutrients
Published
2025-03-20
DOI
https://doi.org/10.3390/nu17061086
Citations
1
Primary Topic
Cancer-related molecular mechanisms research
Type
article
Field-Weighted Citation Impact
0.94
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article

Genome-Wide Impact of Folic Acid on DNA Methylation and Gene Expression in Lupus Adipocytes: An In Vitro Study on Obesity

Leandro Montes Pedroza Carvalho, Chiara Caponi, Amanda Ribeiro, Marcela Augusta Souza Pinhel et al.
1 citations
Nutrients
Cancer-related molecular mechanisms research
0.94
article

Genome-Wide Impact of Folic Acid on DNA Methylation and Gene Expression in Lupus Adipocytes: An In Vitro Study on Obesity

Leandro Montes Pedroza Carvalho, Chiara Caponi, Amanda Ribeiro, Marcela Augusta Souza Pinhel, Carla Barbosa Nonino, Carolina Ferreira Nicoletti, Ana B. Crujeiras, Ángel Díaz‐Lagares, Andrea G. Izquierdo, Nicolás Costa‐Fraga, Jhulia C N L da Mota, Leticia L. Souza
article en
1 citations

Abstract

Folic acid treatment exerts distinct epigenetic and gene expression effects in adipocytes of SLE patients, modulated by obesity status. This weight-dependent response, marked by changes in pathways relevant to immune and metabolic function, highlights the need for further investigation into how nutrient-based interventions might support SLE management. From a clinical perspective, this study underscores the potential of targeted nutrient-based interventions to address immunometabolic dysfunctions in SLE patients. Further research could explore folic acid supplementation as a complementary approach to personalized treatment strategies, particularly for patients with obesity.

NutrientsVol. 17(6)
Faculdade de Medicina de São José do Rio Preto (BR), Universidade de São Paulo (BR), Instituto de Salud Carlos III (ES), Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES), Complejo Hospitalario Universitario de Santiago (ES), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR), Instituto de Investigación Sanitaria de Santiago (ES), Servicio Gallego de Salud (ES), Centro de Investigación Biomédica en Red de Cáncer (ES)
Good health and well-being
Openalex Percentile: Top 27%
Cancer-related molecular mechanisms research
0.94
DOIOpen Access PDFOpenAlex
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