DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer
We establish that SCLC can be classified into one of three distinct, clinically relevant DDR clusters. Our data demonstrates that DDR status plays a key role in shaping SCLC phenotypes and may be associated with different chemotherapy responses and patterns of tumor evolution. Future work targeting DDR specific phenotypes will be instrumental in improving patient outcomes.
Authors
- Vito Quaranta (ORCID: https://orcid.org/0000-0001-7491-8672)
- C. Allison Stewart
- Benjamin B. Morris (ORCID: https://orcid.org/0000-0001-7415-7703)
- Edurne Arriola (ORCID: https://orcid.org/0000-0001-8960-7519)
- Simon Heeke (ORCID: https://orcid.org/0000-0002-5916-534X)
- Barzin Y. Nabet (ORCID: https://orcid.org/0000-0002-4824-3533)
- Kavya Ramkumar (ORCID: https://orcid.org/0000-0002-5864-2204)
- Kyle Concannon (ORCID: https://orcid.org/0000-0001-8445-6328)
- Myung Chang Lee (ORCID: https://orcid.org/0000-0002-7051-5822)
- Pedro Rocha (ORCID: https://orcid.org/0000-0003-3221-7354)
- John Victor Heymach (ORCID: https://orcid.org/0000-0001-9068-8942)
- David S. Shames (ORCID: https://orcid.org/0000-0002-5900-1177)
- Carl M. Gay (ORCID: https://orcid.org/0000-0002-4907-0718)
- Darren R. Tyson (ORCID: https://orcid.org/0000-0002-3272-4308)
- Robert J. Cardnell (ORCID: https://orcid.org/0009-0005-6203-0234)
- Lauren A. Byers (ORCID: https://orcid.org/0000-0002-0780-2677)
- Yuanxin Xi (ORCID: https://orcid.org/0000-0001-5509-2043)
- Lixia Diao (ORCID: https://orcid.org/0000-0001-6995-4492)
- Qi Wang (ORCID: https://orcid.org/0000-0002-5287-6050)
- Jing Wang (ORCID: https://orcid.org/0000-0002-4744-9580)
- Runsheng Wang (ORCID: https://orcid.org/0000-0002-8016-5934)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Vanderbilt University (US)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Del Mar (ES)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s12943-025-02291-0
- Citations
- 6
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- Neuroendocrine Tumor Research Foundation
- Andrew Sabin Family Foundation