Metabolic stress and age drive inflammation and cognitive decline in mice and humans
Metabolic stress causes persistent metabolic and cognitive impairments in mice. Murine and human brain spatial transcriptomics align and indicate a pro-inflammatory milieu. Transcriptomic data indicate a role for microglial-mediated inflammatory mechanisms. Secreted phosphoprotein 1 emerged as a potential target of interest in metabolically driven cognitive impairment.
Authors
- Rosemary E. Henn (ORCID: https://orcid.org/0000-0002-7392-1607)
- Kai Guo (ORCID: https://orcid.org/0000-0002-4651-781X)
- Dae‐Gyu Jang (ORCID: https://orcid.org/0009-0009-7966-1322)
- Diana M Rigan (ORCID: https://orcid.org/0000-0003-4564-2130)
- John M. Hayes (ORCID: https://orcid.org/0000-0002-5677-2216)
- Ian Webber‐Davis
- Sarah E. Elzinga (ORCID: https://orcid.org/0000-0002-4219-2712)
- Ali Turfah
- Emily Glass
- Adam M. Allouch (ORCID: https://orcid.org/0009-0008-1093-5252)
- Geoffrey G. Murphy (ORCID: https://orcid.org/0000-0003-3691-1722)
- Eva L. Feldman (ORCID: https://orcid.org/0000-0002-9162-2694)
- Samuel J. Teener (ORCID: https://orcid.org/0009-0003-9072-8184)
- Stephen I. Lentz (ORCID: https://orcid.org/0000-0003-1686-7998)
- Junguk Hur (ORCID: https://orcid.org/0000-0002-0736-2149)
- Crystal Pacut
- Andrew Carter (ORCID: https://orcid.org/0009-0006-7953-8998)
- Kevin S. Chen (ORCID: https://orcid.org/0000-0003-0738-3799)
- Rachel Parent
- Lili Zhao (ORCID: https://orcid.org/0000-0002-6366-8206)
Institutions
- University of North Dakota (US)
- University of Michigan (US)
- Michigan Medicine (US)
- Michigan State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.70060
- Citations
- 11
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 9.26
Funders
- Alzheimer's Association
- Sinai Medical Staff Foundation
- National Institutes of Health