Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK/Drp1 pathway
This study provides the first evidence that Piezo1 is elevated in DCM through the modulation of mitochondrial dynamics, which is reversed by Piezo1 deficiency. Thus, Piezo1 inhibition may provide a promising therapeutic strategy for the treatment of DCM.
Authors
- Tianying Hong
- Cuifen Wang
- Jiali Liu (ORCID: https://orcid.org/0009-0004-6492-9393)
- Yuehua Jiang (ORCID: https://orcid.org/0000-0003-0156-0715)
- Weipin Niu
- Jing Li (ORCID: https://orcid.org/0000-0002-6896-3474)
- Xin Liu (ORCID: https://orcid.org/0009-0001-9842-1422)
- Bo Deng (ORCID: https://orcid.org/0000-0002-5112-9221)
- Yameng Yan
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Shandong Institute of Commerce & Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s12933-025-02625-8
- Citations
- 13
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 15.14
Funders
- National Natural Science Foundation of China