Anti-Glycation Activities of Angelica keiskei Leaves

The screening of a small library of Japanese herbal tea extracts revealed significant anti-glycation activity in the leaves of <i>Angelica keiskei</i>. LC-MS analysis led to the identification of twenty compounds in this herb tea, including seven flavonoids, five phenylpropanoids, and eight coumarin derivatives, based on their chromatographic behavior and fragmentation patterns. Further LC-MS analysis of the methanol-eluted fraction after incubation with methylglyoxal (MGO) was performed on the reaction mixture, revealing quercetin 3-<i>O</i>-glucoside to be a key compound contributing to the anti-glycation activity of the leaves.