Intercellular Communication Network of CellChat Uncovers Mechanisms of Kidney Fibrosis Based on Single-Cell RNA Sequencing
This study elucidates the potential mechanisms by which Empa slows the progression of renal fibrosis in nondiabetic CKD. By reducing the number of M2 macrophages and inhibiting signal transduction in both pro-inflammatory and fibrotic pathways, Empa modulates the intercellular communication network in renal cells, offering a promising therapeutic strategy for CKD management.
Authors
- Tian-Jiao Cui
- Mao Luo (ORCID: https://orcid.org/0000-0002-9076-7875)
- Berthold Hocher (ORCID: https://orcid.org/0000-0001-8143-0579)
- Zeyu Zhang (ORCID: https://orcid.org/0000-0002-8703-4195)
- Zhihua Zheng (ORCID: https://orcid.org/0000-0003-1025-5384)
- Thomas Klein (ORCID: https://orcid.org/0000-0001-5762-9166)
- Hongwei Wu (ORCID: https://orcid.org/0000-0002-1775-5042)
- Yvonne Liu (ORCID: https://orcid.org/0000-0002-5688-2108)
- Yongping Lu
- Ting Zhu (ORCID: https://orcid.org/0000-0003-3542-7023)
- Xue‐Mei Zhang (ORCID: https://orcid.org/0000-0001-6000-6146)
- Lei Lei (ORCID: https://orcid.org/0000-0001-5372-8749)
- Xiao Hua Wang (ORCID: https://orcid.org/0000-0002-1774-6189)
- Yun-Xiu Xiang
- Chun Tang (ORCID: https://orcid.org/0000-0002-9356-0116)
- Denis Delić (ORCID: https://orcid.org/0000-0001-6798-3134)
- Bernhard Krämer
Institutions
- Boehringer Ingelheim (Germany) (DE)
- Central South University (CN)
- Sun Yat-sen University (CN)
- Heidelberg University (DE)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Reproductive & Genetic Hospital CITIC-Xiangya (CN)
- Guangzhou Liwan District Traditional Chinese Medicine Hospital (CN)
- CS Diagnostics (DE)
- University Medical Centre Mannheim (DE)
- First Affiliated Hospital of Jinan University (CN)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Kidney & Blood Pressure Research
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1159/000545209
- Citations
- 5
- Primary Topic
- Renal and Vascular Pathologies
- Type
- article
- Field-Weighted Citation Impact
- 7.59