Abnormal DNA methylation of EBF1 regulates adipogenesis in chicken
A combination of WGBS and RNA-seq analyses revealed 48 DMGs in the abdominal fat tissue of chickens. Notably, the DNA methylation status of EBF1 was inversely related to its mRNA expression. Mechanistically, DNA methylation regulates EBF1 expression, which in turn mediates the differentiation of ICP-1 through the PPARγ pathway. This study provides a theoretical framework for investigating the effects of DNA methylation on adipogenesis in chickens.
Authors
- Zhenhui Li (ORCID: https://orcid.org/0000-0001-7221-2588)
- Meiling Hu
- Xiquan Zhang (ORCID: https://orcid.org/0000-0002-7940-1303)
- Xiaohuan Chao (ORCID: https://orcid.org/0009-0009-3324-809X)
- Kang Luan
- Mao Ye (ORCID: https://orcid.org/0000-0002-7878-5608)
- Chunlei Zhang (ORCID: https://orcid.org/0000-0001-8076-143X)
- Yijie Liu (ORCID: https://orcid.org/0009-0007-3959-8993)
- Lijin Guo (ORCID: https://orcid.org/0000-0001-5919-9980)
- Zhexia Fan
- Bo Zhou (ORCID: https://orcid.org/0000-0001-6611-8608)
- Qingbin Luo (ORCID: https://orcid.org/0000-0003-0679-1387)
- Jiahao Chen (ORCID: https://orcid.org/0000-0002-1515-2424)
Institutions
- South China Agricultural University (CN)
- Nanjing Agricultural University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s12864-025-11464-6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Municipal Science and Technology Project