Prevalence and Associated Explanatory Factors for Augmented Renal Clearance in Early Sepsis: Single-Center, Retrospective PICU Cohort in China, 2022–2023
In this retrospective cohort of pediatric sepsis patients admitted to the PICU, the prevalence of early-onset ARC is around 50%, and younger patients may be at risk. The presence of ARC is associated with hemodynamic and inflammatory responses. Taken together, more prospective work is needed, with an emphasis on drug-level targeting and a better understanding of interactions with intrarenal pathophysiology.
Authors
- Zhushengying Ma
- Jiayue Xu (ORCID: https://orcid.org/0000-0002-6633-6522)
- Haoyun Mao (ORCID: https://orcid.org/0009-0006-6794-3523)
- Lili Xu (ORCID: https://orcid.org/0000-0001-6724-6257)
- Yueniu Zhu (ORCID: https://orcid.org/0009-0000-3632-4224)
- Yaya Xu (ORCID: https://orcid.org/0000-0003-4193-6035)
- Wen Qian (ORCID: https://orcid.org/0000-0002-4260-4625)
- Yuru Zhang
- Xiaodong Zhu (ORCID: https://orcid.org/0000-0002-4083-5569)
Institutions
- Apple (Israel) (IL)
- XinHua Hospital (CN)
- La Salle University (US)
Publication Details
- Journal
- Pediatric Critical Care Medicine
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1097/pcc.0000000000003727
- Citations
- 4
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 5.72