Effects of Daily Lifestyle Habits on Non-Neurogenic Orthostatic Hypotension in Older Adults in South Korea: A Cross-Sectional Study

<b>Background:</b> Orthostatic hypotension (OH) is a chronic, debilitating condition common in older adults. This study examined the effects of daily lifestyle habits on non-neurogenic OH in older adults in South Korea. We further compared the effects of daily lifestyle habits on OH to those of the autonomic nervous system (ANS) function. <b>Methods:</b> In a cross-sectional study, 217 community-dwelling older adults aged ≥65 years were recruited using the convenience sampling method. Data were collected using two questionnaires to assess OH and daily lifestyle habits: OH was measured by Orthostatic Grading Scale (OGS) and lifestyle habits included nutrition, sleep, physical activity, and psychological status (stress and depression levels). Plasma catecholamines (epinephrine and norepinephrine) were measured to indicate the ANS function. The data were analyzed using <i>t</i>-tests, Pearson's correlation coefficients, and multiple linear regression analysis. <b>Results:</b> Significant factors related to OGA score included nutritional status (B = -0.20, <i>p</i> ≤ 0.040), poorer sleep quality (B = 0.15, <i>p</i> = 0.005), physical activity (B = -0.01, <i>p</i> = 0.032), stress (B = 0.04, <i>p</i> = 0.001), and depression (B = 0.23, <i>p</i> = 0.001). These together explained 40.5% of the variance in OH. However, no significant association was found between catecholamines and OGS score. <b>Conclusions:</b> These results suggest that lifestyle habits are important factors, while ANS function may be less associated with non-neurogenic OH. Thus, preventive and non-pharmacological interventions for decreasing OH symptoms should focus on maintaining healthy lifestyle habits in older adults.